Publications

1α,25-Dihydroxyvitamin D Inhibits the Metastatic Capability of MCF10CA1a and MDA-MB-231 Cells in an In Vitro Model of Breast to Bone Metastasis. Wilmanski T, Barnard A, Parikh MR, Kirshner J, Buhman K, Burgess J, Teegarden D. Nutr Cancer. 2016 Oct;68(7):1202-9. doi: 10.1080/01635581.2016.1213868. Epub 2016 Aug 23.

Maytansinoid immunoconjugate IMGN901 is cytotoxic in a three-dimensional culture model of multiple myeloma. Nierste BA, Gunn EJ, Whiteman KR, Lutz RJ, Kirshner J. Am J Blood Res. 2016 May 18;6(1):6-18. eCollection 2016.

A reconstructed metastasis model to recapitulate the metastatic spread in vitro. Parikh MR, Minser KE, Rank LM, Glackin CA, Kirshner J. Biotechnol J. 2014 Sep;9(9):1129-39. doi: 10.1002/biot.201400121. Epub 2014 Jul 7.

Differentiation of cancer cells in two-dimensional and three-dimensional breast cancer models by Raman spectroscopy. Damayanti NP, Fang Y, Parikh MR, Craig AP, Kirshner J, Irudayaraj J. J Biomed Opt. 2013 Nov;18(11):117008. doi: 10.1117/1.JBO.18.11.117008.

The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma. Gunn EJ, Williams JT, Huynh DT, Iannotti MJ, Han C, Barrios FJ, Kendall S, Glackin CA, Colby DA, Kirshner J. Leuk Lymphoma. 2011 Jun;52(6):1085-97. doi: 10.3109/10428194.2011.555891. Epub 2011 Mar 21.

In a patient with biclonal Waldenstrom macroglobulinemia only one clone expands in three-dimensional culture and includes putative cancer stem cells. Kirshner J, Thulien KJ, Kriangkum J, Motz S, Belch AR, Pilarski LM. Leuk Lymphoma. 2011 Feb;52(2):285-9. doi: 10.3109/10428194.2010.535183. Epub 2010 Dec 6.

A unique three-dimensional model for evaluating the impact of therapy on multiple myeloma. Kirshner J, Thulien KJ, Martin LD, Debes Marun C, Reiman T, Belch AR, Pilarski LM. Blood. 2008 Oct 1;112(7):2935-45. doi: 10.1182/blood-2008-02-142430. Epub 2008 Jun 5.

Mutation analysis of the short cytoplasmic domain of the cell-cell adhesion molecule CEACAM1 identifies residues that orchestrate actin binding and lumen formation. Chen CJ, Kirshner J, Sherman MA, Hu W, Nguyen T, Shively JE. J Biol Chem. 2007 Feb 23;282(8):5749-60. Epub 2006 Dec 27.

CEACAM1, a cell-cell adhesion molecule, directly associates with annexin II in a three-dimensional model of mammary morphogenesis. Kirshner J, Schumann D, Shively JE. J Biol Chem. 2003 Dec 12;278(50):50338-45. Epub 2003 Sep 30.

CEACAM1-4S, a cell-cell adhesion molecule, mediates apoptosis and reverts mammary carcinoma cells to a normal morphogenic phenotype in a 3D culture. Kirshner J, Chen CJ, Liu P, Huang J, Shively JE. Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):521-6. Epub 2003 Jan 9.