Our Reconstructed Organ technology is a set of organ-specific 3D culture platforms formulated based on the composition of the native microenvironment of human tissues. Each organ platform is available in 2 formats: a 3D Bioassay (a comprehensive system with extracellular matrix, medium additives, and buffers) and a Basic 3D Matrix Pack (extracellular matrix only).

Tissue structure of r-Bone is indistinguishable from bone marrow architecture in vivo

Reconstructed Bone Marrow (r-Bone™) system recapitulates the comprehensive 3D microenvironment of the human bone marrow supporting proliferation of the hematopoietic and stromal compartments while retaining the composition and 3D architecture of in vivo tissue. r-Bone maintains long-term viability of primary bone marrow cells and, as such, provides a unique platform to predict efficacy of new therapeutics.

in vivo bone marrow

Cryo-electron microscopy of bone marrow organ reconstructed in r-Bone model compared to in vivo bone marrow.

r-Bone promotes proliferation and long-term viability of primary Multiple Myeloma and AML

Blood cancers such as multiple myeloma (MM) and acute myelogenous leukemia (AML) originate and grow within the bone marrow. The r-Bone-MM and r-Bone-AML systems recapitulate the physiological and pathological conditions of the bone marrow from patients with multiple myeloma and AML respectively. The comprehensive 3D microenvironment of r-Bone provides a robust system to predict efficacy of novel therapeutics and combination treatments.

r-Bone maintains robust proliferation and long-term viability of primary AML cells compared to conventional 2D cultures.

Reconstructed organ Workflow

r-Bone 3D Bioassay Kit Contents

  • r-Endosteum Matrix
    extracellular matrix (ECM) formulated to recapitulate the composition of the human endosteum (connective tissue between bone and bone marrow).

  • r-Bone Matrix
    extracellular matrix (ECM) proteins formulated to recapitulate the ECM composition of the human bone marrow.

  • r-Bone Supplement
    growth medium supplement representing the growth factor / hormone / cytokine microenvironment of the bone marrow

  • r-Bone Cocktail
    growth medium additives formulated to supply extracellular factors to reconstruct bone marrow microenvironment

  • Cell Isolation Solution
    a buffer used to isolate viable cells from the r-Bone

Ordering information


Multiple Myeloma (MM)


r-Bone 3D Bioassay

Catalog #



Contact us

Acute Myelogenous Leukemia (AML)

r-Bone 3D Bioassay


Reconstructed Bone Marrow

r-Bone Basic 3D Matrix Pack*

*ECM only, growth medium supplements to be provided by the user.




Contact Us

We're not around right now. But you can send us an email and we'll get back to you, asap.

Not readable? Change text. captcha txt

Start typing and press Enter to search