September, 2018

Here we describe the Reconstructed Bone (r-Bone™) technology, a patient-derived 3D tissue culture model where the human bone marrow microenvironment is reconstructed in vitro. The r-Bone system mimics the cellular and extracellular environment of the bone marrow and, as such, is capable of supporting long-term survival and expansion of primary multiple myeloma cells and cells from other hematological malignancies.

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