Patient-Derived Organ-Specific 3D Cell Culture

Cancer cell lines

Spheroid models for cancer cell lines from solid tumors and hematological malignancies.

Cells cultured in 3D embedded in our proprietary organ-specific ECM provide a far more accurate readout of the drug response compared to the conventional cell culture models.

Primary cells

Patient-derived models utilizing primary tumor cells grown in 3D in organ-specific ECM with disease-specific medium supplements. The resulting reconstructed tumor microenvironment provides a physiologically relevant platform to assess the efficacy and toxicity of anti-cancer agents.

These patient-derived models demonstrate high correlation with clinical response enabling elimination of ineffective compounds early in the drug development process.

Co-culture/multi-compartment

Co-cultures of tumor epithelium with stroma and immune components. Organ-specific 3D models incorporate epithelial spheroids formed by cancer cell lines, primary cancer-associated fibroblasts (CAFs) or primary non-malignant stroma, with or without immune lymphoid/myeloid immune cells.

Reconstructed Metastasis (r-Met) model is a multi-compartment system enabling fractionation of tumor cells into primary, invasive, and metastatic cell populations. This is the only available model that provides access to the metastatic cells for target discovery and drug testing. 

High throughput (HTS)

High throughput format of the cell line spheroid models utilizes automated set-up, treatment, and readout for rapid screening of large sets of anti-cancer agents while maintaining the physiological tissue architecture provided by our proprietary organ-specific ECM.